Starting HIV Post-Exposure Prophylaxis (PEP) is a big step in protecting yourself after possible exposure to HIV. But one of the most common challenges people face is forgetting a dose. Since PEP must be taken daily for 28 days to work effectively, a missed dose can make you anxious. Here’s what you need to know.

I missed a PEP dose, what should I do?

If it’s less than 24 hours since your missed dose:

• Take the tablet as soon as you remember. Then continue your next dose at the usual time.

If it’s almost time for your next dose (within 6 hours):

• Skip the missed dose and just take your next one at the scheduled time. Do not double up.

Will one missed dose make PEP fail?

Missing one dose is unlikely to make PEP fail, especially if you take the rest of your medication correctly. What matters is that you:

• Take your pills consistently
• Avoid missing doses repeatedly
• Complete the full 28-day course

What if I missed more than one dose?

Missing two or more doses in a row lowers the effectiveness of PEP. Contact a healthcare provider immediately to discuss whether you should restart the course or continue.

How can I avoid missing doses in the future?

• Set alarms or phone reminders
• Keep your pills where you can see them daily
• Carry a backup dose in your bag if you’ll be away from home
• Link your dose to a routine activity (e.g., brushing teeth at night)

Bottom Line

PEP is most effective when taken every day, at the same time, for 28 days. Don’t panic if you miss a single dose, just take it as soon as you remember. But repeated missed doses can reduce protection, so staying consistent is key.

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